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Biotechnology & Clinical research in Bangladesh

Biotechnology & Clinical research in Bangladesh

Present Global Trends:
Technology-based companies are taking a fresh look at developing countries for potential trade partners with access to biologically diverse resources. Although an estimated 25% of all prescription drugs come from botanical sources, recent advances in automated selections and screens along with combinatorial chemistry have promoted the rapid growth of agricultural biotechnology. Companies such as Abbott, Bristol-Myers Squib and Eli Lilly have been active players in botanical bioprospecting for more than fifty years and other major companies such as Bayer, SmithKline Beecham, Glaxo Wellcome, Biodiversity, Aventis and Merck have shown a strong interest to invest in developing countries.
Reference: bioinformaticsmarketsize.787179.free-press-release.com/

Global Market Size:
The global bioinformatics industry has been witnessing double-digit growth rate for the past decade due to ongoing research. As per our new research report Global Bioinformatics Market Outlookthe market for bioinformatics will surge at a CAGR of nearly 26% during 2011-2013.
Reference: http://www.rncos.com/Press_Releases/Bioinformatics-Market-to-Grow-at-26-CAGR-by-2013.htm

The global bioinformatics market size was at USD 3 billion in 2010 and will grow up to USD 8 billion in 2014 (Business Insights, 2009).
Reference: http://www.mitarabcompetition.com/semifinalists/eg-bioinformatics.php

In 2015 with $900M for Research applications and $550M for Clinical, the total market size for genome projects alone are estimated at $1.45B.
Reference: http://nextgeninformatics.com/2011/01/18/market-for-bioinformatics/

Why Bangladesh?

  • Areas that have developed in the past decade are as follows:
    • Plant tissue culture: Protocols on plant regeneration and micro propagation have been developed on different crops, forest plants, ornamental and fruit trees as well as vegetables.
  • Work has been initiated on Agrobacterium mediated genetic transformation of :
    • Rice, jute, oil seed, potato, chickpea, papaya for insect, fungus and virus resistance; genetic transformation of pulses for fungus resistance, salinity and drought tolerance; and nutritional enrichment/improvement.
  • Bangladesh is the 2nd country in the developing world to decode the complete genome for Jute.
  • An example of the kind of work that was done with the genome project:

“Recently, research in some universities in the Indian subcontinent has resorted to molecular approaches through systematic cloning and transgenic work. By means of a combined study of AFLP and RAPD, Hossain et al. (2002, 2003) at Dhaka University have shown the importance of using molecular markers in distinguishing between cold-tolerant and cold sensitive jute varieties obtained from GenBank at Bangladesh Jute Research Institute (BJRI). Using simple sequence repeat (SSR) marker loci and AFLP assay, Basu et al. (2004) at the Indian Institute of Technology (IIT), Kharagpur, evaluated genetic diversity of 49 genotypes of the two jute species. More recently, P. K. Gupta at Charan Singh University, Meerat (CSUM), India and his associates as well as the Dhaka University team led by Haseena Khan developed genomic SSRs and deposited the sequences in GenBank. By developing more SSRs Gupta and his team at CSUM are planning to embark upon a program of gene tagging combined with the construction of a framework linkage map for QTL interval mapping. In addition to the research on markers, procedure for successful regeneration (Seraj Preliminary Progress in Jute (Corchorus spp.) Genome Analysis 147 et al. 1992; Saha et al. 1999) and transformation of C. capsularis (Ghosh et al. 2002)
have been developed.”

Reference: http://www.defence.pk/forums/bangladesh-defence/62065-bangladesh-decodes-jute-plant-genome.html

  • Rich genetic resources of plant, animal, and aquatic fauna
  • Availability of graduate and post-graduate programme on biotechnology and relevant subjects. 16 universities including 4 private universities are offering graduate and post graduate degree  specially on biotechnology in our country.
  • Policy level support for research and development of biotechnology
  • Access to databases and modern communication technologies.
  • Research opportunities for Food safety & security and environmental protection and health. Researchers in the government research institutes and universities are trying to produce bioengineered varieties of rice, jute, pulses, oilseeds, and vegetables, mostly for higher yields, disease resistance, and stress tolerance etc. Tissue cultured crops of various vegetables, forest plants, ornamental, fruit trees and medicinal plants are in commercial cultivation.
  • The private sectors that are interested in biotechnology research and development include a number of private entrepreneurs and NGOs are 3 involved on Plant tissue culture, virus-free potato seed production in substantial quantities, reducing our dependency gradually on imported potato seeds. Considerable progress has been achieved in developing transgenic plants of some key crop plants (rice jute, brinjal, grain legumes, potato, etc.) in the country.

Some of the Organizations that work on biotech R&D:

  • Bangladesh Livestock Research Institute (BLRI)
  • Bangladesh Agricultural University (BAU)
  • National Institute of Biotechnology (NIB)

History of  Research & Development:

  • Animal Biotechnology, including molecular characterization of native animals, embryo transfer technology, multiple ovulation, artificial insemination, identification of pathogen
  • PCR based diagnosis of avian influenza in poultry and foot and mouth disease in cattle have been initiated.
  • Vaccine for goat plague is being used at farmer’s level.
  • Developments in fish Biotechnology include:
    • Induced breeding techniques in carp, pabda, catfish, koi and others; genetic stock improvement of indigenous and exotic carp and tilapia through selective breeding
    • Production of monosex population (all males and all females) in tilapia and silver carp by sex reversal and chromosome manipulation technique; detection of introgressed hybrids in carps in the hatcheries using micro satellite DNA markers
    • Stock discrimination of hilsa by allozyme and DNA-RFLP markers.